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Why Psychedelics Might Be the Breakthrough That PTSD Patients Need (Kevin Ryan, The Godfather of NYC Tech)

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Often called the godfather of NYC tech, Kevin Ryan is one of America’s most influential entrepreneurs and investors. He co-founded MongoDB, Business Insider, Gilt Groupe, Zola, and Transcend Therapeutics, and continues to build and back new companies each year through AlleyCorp. Earlier in his career, he led DoubleClick from a 20-person startup to a global leader, taking it public before its acquisition by Google.In this episode, Kevin shares his insights on two surprising pockets of the future that he’s betting on: psychedelics for mental health and AI-powered materials science.

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Uploaded May 26, 2026
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Speaker A: Everyone is tempted because if you start a company for very little money, you might own 50% of it, which makes it seem easy. But on the other hand, can you get the right entrepreneur? Can you build it up? Can you build the team? Can you do the right things? Speaker B: You mentioned finding the right entrepreneur. Is that sort of the hardest part of the equation in your experience and where most folks fall foul of it? Speaker A: Look, at the end of the day, a company is very simple.

You need an idea and a great team. It's doing it that's hard. So there aren't that many great ideas. There aren't that many great teams. So you have to get both of them right. Speaker B: What are some of the themes that you are excited about when you look at 2035 that are top of mind for you right now? Speaker A: Clearly, we're not the only people AI ripples through every single thing we do. Even our robotics practice, which felt like a mechanical engineering project 6 years ago, is now largely an AI-driven product.

And so using AI tools correctly, making sure we're doing a good job on sourcing. If AI has an impact on jobs, what does that mean for retraining companies? What is going to be protected? Speaker B: What isn't? Speaker C: Hey, I'm Mario. Speaker B: And this is the Generalist Podcast. As the saying goes, the future is already here. It's just not evenly distributed. Each week I sit down with the founders, investors, and thinkers who are living in the future to help you see what's coming next and capitalize on it. Today I'm speaking with Kevin Ryan, the founder and CEO of AlleyCorp.

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